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Natural Relief From Chronic Fatigue & Stress
Hypothalamic-Pituitary-Adrenal (HPA) axis dysfunction, also called “adrenal fatigue,” is an epidemic in the United States and is primarily caused by excessive actual and/or perceived (mental) stress. Over 80% of people cite lack of energy, a common HPA axis dysfunction symptom, as the most common reason for going to a physician. Other symptoms that may indicate HPA axis dysfunction includes the uncontrollable urge to eat, constant sugar cravings, unusual mood swings, chronic fatigue during the day and an inability to fall asleep at night.
THE STRESS RELIEF DIFFERENCE
Stress Relief is a natural, adaptogenic, stimulant free formula that rehabilitates the body’s energy systems and adrenal glands by balancing cortisol levels and the body’s stress response. Stress Relief works at the cellular level in the brain, adrenal gland and gut to efficiently recharge the exhausted person.
Pantothenic Acid (B5) is involved in the production of important stress management hormones, including cortisol and progesterone2,3. In addition, pantothenic acid has been shown to increase acetyl CoA levels in the body, leading to increased cellular energy production4 .
Rhodiola Rosea Root Extract
Rhodiola is a powerful adaptogenic herb that has been widely used in Eastern Europe and Asia. A great deal of research has shown its efficacy helping support the nervous system, mood regulation, mental clarity, work performance and the sleep cycle5. A six week randomized, placebo controlled, double-blind study using 170 mg of Rhodiola showed a clear anti-fatigue effect without any reported adverse reactions for those in the treatment group6 . Another double blind, randomized trial using Rhodiola found that those using the treatment experienced increased mental performance, especially the ability to concentrate7.
Ashwaganda (Withania somnifera) is a powerful, adaptogenic herb that helps the body deal with stressors. Sensoril Ashwaganda® is a unique, patented form of Ashwagandha that is prepared in a way that leads to higher levels of its active constituents (withanolide glycosides) compared to conventional preparations. The ingredient is supported by ten clinical trials. One double-blind, placebo controlled trial showed that 250 mg of the ingredient (amount in a daily dose of Stress Relief) was able to decrease cortisol levels by 24.2%, increase DHEA sulfate levels by 32.2% and decrease C-reactive protein (CRP) levels, an inflammatory marker, by 36.6% in 60 days8. The same dose elicited the following symptomatic improvements in the same time period: 73% for fatigue, 68% for sleeplessness, 57% for forgetfulness, 77% for irritability, 75% for depression, 71% for headache and muscle pain and 76% for ability to concentrate. In another double-blind placebo controlled trial using the same ingredient at various doses showed that 250 mg improved knee swelling (6%), pain (35%), stiffness (31%), and disability (34%) and an overall 29% improvement in mWOMAC scores, a widely used scale derived from a set of standardized questionnaires used to evaluate osteoarthritis symptoms9.
Eleuthero Root Extract (Siberian Ginseng)
Eleuthero is considered by some to be the master “adaptogenic” herb, as it is the botanical that seems to be extremely effective at promoting physiological homeostasis in the body. It has been shown to support general health, memory and endurance10 as well as immune function11,12. Double-blind research has shown Eleuthero’s ability to help maintain a sense of calmness by reducing heart rate13 and improve performance in runners14.
This gentle amino acid is naturally found in green tea and has been shown to promote relaxation without causing drowsiness by increasing alpha waves in the brain. Alpha waves are known to induce an alert and relaxed mental and physical state. Research has shown that L-theanine reaches the brain and increases alpha wave activity within 40 minutes of ingestion15 . L-theanine may also support healthy blood pressure levels and improve learning ability.
Super Oxide Dismutase (SOD)
SOD is one of the body’s strongest antioxidants. It helps repair cells and minimizes cellular damage by neutralizing free radicals that would normally cause damage to body tissues and create inflammation. It was shown that mammals who produced higher tissue and serum levels of SOD lived longer than those with lower levels 16,17.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
As a dietary supplement, take one (1) capsule three times per day or as directed by your healthcare professional.
Do not take this product if you are pregnant or nursing. As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you anticipate surgery, take any medication or are otherwise under medical supervision.
Wheat, soy, dairy, eggs, fish, crustacean shellfish, tree nuts, peanuts, artificial preservatives, sweeteners, colors and flavors.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
References and Research Abstracts Supporting Stress Relief
1. What is Adrenal Fatigue? (n.d.). Retrieved October 22, 2015. https://www.adrenalfatigue.org/what-is-adrenal-fatigue
2. Jaroenporn, S., Yamamoto, T., Itabashi, A., Nakamura, K., Azumano, I., Watanabe, G., & Taya, K. (2008). Effects of pantothenic acid supplementation on adrenal steroid secretion from male rats. Biological and Pharmaceutical Bulletin, 31(6), 1205-1208.
3. European Food Safety Authority: Scientifi c Opinion on the substantiation of health claims related to pantothenic acid and mental performance (ID 58), reduction of tiredness and fatigue (ID 63), adrenal function. Retrieved from:http://www.efsa.europa.eu/en/efsajournal/doc/1758.pdf
4. Slyshenkov VS, Dymkowska D, Wojtczak, L. Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. FEBS Lett 2004; 569 (1-3):169-172.
5. Rhodiola rosea. Altern Med Review 2002;7 (5):421-423
6. Darbinyan, V., Kteyan, A., Panossian, A., Gabrielian, E., Wikman, G., & Wagner, H. (2000). Rhodiola rosea in stress induced fatigue—a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.Phytomedicine, 7(5), 365-371.
7. Olsson, E. M., von Schéele, B., & Panossian, A. G. (2009). A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta medica, 75(2), 105.
8. Abedon, Bruce, and Shibnath Ghosal. "A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study." (2008).
9. Ramakanth, G. S. H., Kumar, C. U., Kishan, P. V., & Usharani, P. (2016). A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain. Journal of Ayurveda and integrative medicine, 7(3), 151-157.
10. American Botanical Council. American Botanical Council.
Eleuthero root. http://www.herbalgram.org. 2002.
11. Melchior J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Ness extract fixed combination (Kan jang) in the treatment of uncomplicated upper-respiratory tract infection. Phytomedicine 2000;7:341-50.
12. Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97.
13. Facchinetti F, Neri I, Tarabusi M. Eleutherococcus senticosus reduces cardiovascular response in healthy subjects: a randomized, placebo-controlled trial. Stress
Health 2002; 18:11-17.
14. Halstead BW, Hood LL. Eleutherococcus senticosus /Siberian ginseng: An introduction to the Concept of Adaptogenic Medicine. Long Beach, CA:Oriental Healing Arts Institute; 1984:28.
15. Juneja, L. R., Chu, D. C., Okubo, T., Nagato, Y., & Yokogoshi, H. (1999). L-theanine—a unique amino acid of green tea and its relaxation effect in humans. Trends in Food Science & Technology, 10(6), 199-204.
16. Cutler RG. Antioxidants and longevity of mammalian species. Basic Life Sci. 1985;35:15-73.
17. Cutler RG. Antioxidants and aging. Am J Clin Nutr. 1991 Jan;53(1 Suppl):373S-9S. - See more at: http://www.lifeextensionvitamins. com/suoxdispopra1.html#sthash.iEp5av32.dpuf
- Lifesaver! Review by Laura